近藤 寛子 Kondo Hiroko X.

学位

職歴

担当授業科目（学部）

バイオ食品工学実験II　ﾊﾞｲｵ食品, 工学基礎実験および演習 地域未来/短期履修, 基礎生物学　地球環境/短期履修, 基礎生物学　地域未来/短期履修, 生物物理学　ﾊﾞｲｵ食品

専門分野

生物物理学，分子動力学シミュレーション, バイオインフォマティクス

研究テーマ

ヘムの機能制御を目的としたディープラーニングおよび量子化学計算によるヘム蛋白質の網羅解析, 蛋白質の分子内相互作用の高次構造依存性の解明

研究内容キーワード

分子動力学, 機械学習, ディープラーニング, バイオインフォマティクス, 構造活性相関

所属学会

日本生物物理学会, 日本蛋白質科学会

学術論文

論文名／掲載誌名等		掲載年月
Free-energy landscapes of protein domain movements upon ligand binding The Journal of Physical Chemistry B, 115, 23, 7629		2011-06
Structural basis for the membrane association of ankyrinG via palmitoylation Scientific Reports, 6, 23981		2016-04
The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs BMC Evolutionary Biology, 18, 3		2018-01
アンキリンが生体膜に相互作用する構造基盤 生物物理, 58, 3, 152		2018-05
Zn2+-Binding to the Voltage-Gated Proton Channel Hv1/VSOP The Journal of Physical Chemistry B, 122, 39, 9076-9080		2018-09
Statistical and quantum-chemical analysis of the effect of heme porphyrin distortion in heme proteins: Differences between oxidoreductases and oxygen carrier proteins Chemical Physics Letters, 710, 108-112		2018-10
Molecular mechanism of depolarization-dependent inactivation in W366F mutant of Kv1.2 The Journal of Physical Chemistry B, 122, 48, 10825		2018-11
Hydrogen bond donors and acceptors are generally depolarized in α-helices as revealed by a molecular tailoring approach Journal of Computational Chemistry, 40, 23, 2043-2052		2019-05
電位依存性カリウムチャネルKv1.2の変異体における不活性化の分子機構の解析 アンサンブル, 21, 283		2019-10
Effects of a remote mutation from the contact paratope on the structure of CDR-H3 in the anti-HIV neutralizing antibody PG16 Scientific Reports, 9, 19840		2019-12
Computational study of distortion effect of Fe-porphyrin found as a biological active site Japanese Journal of Applied Physics, 59, 010502		2020-01
PyDISH: database and analysis tools for heme porphyrin distortion in heme proteins Database, 2020, baaa066		2020-10
ヘムタンパク質の機能発現メカニズムの解明に向けたデータベースの整備と機械学習を用いた解析 フロンティア, 3, 1, 29-36		2021-01
Analysis of fluctuation in the heme-binding pocket and heme distortion in hemoglobin and myoglobin Life , 12, 2, 210		2022-01
Global analysis of heme proteins elucidates the correlation between heme distortion and the heme-binding pocket The Journal of Chemical Information and Modeling, 62, 4, 775-784		2022-02
Structure of heme-binding pocket in heme protein is generally rigid and can be predicted by AlphaFold2 Chemistry Letters, 51, 7, 704-708		2022-05
Depolarizing Effects in Hydrogen Bond Energy in 3-10-Helices Revealed by Quantum Chemical Analysis International Journal of Molecular Science , 23, 16, 9032		2022-08
Elucidation of the Correlation between Heme Distortion and Tertiary Structure of the Heme-Binding Pocket Using a Convolutional Neural Network Biomolecules, 12, 9, 1172		2022-08
Conformational Preference of Flavonols and Its Effect on the Chemical Properties Involved in Radical Scavenging Activity Chemistry, 4, 4, 1123-1135		2022-09
Effects of active-center reduction of plant-type ferredoxin on its structure and dynamics: computational analysis using molecular dynamics simulations International Journal of Molecular Science , 23, 24, 15913		2022-12
Quantum chemical studies on hydrogen bonds in helical secondary structures Biophysical Reviews , 14, 1369-1378		2022-12
Prediction of protein function from tertiary structure of the active site in heme proteins by convolutional neural network Biomolecules , 13, 1, 137		2023-01
Negative fragmentation approach on depolarization effect of neighboring residue on hydrogen bond in π-helix Chemical Physics Letters , 815, 140361		2023-02
Random Forest Classifier of Heme Proteins Using Porphyrin Distortions and Axial Ligands of Heme Chemistry Letters, 52, 6, 503-507		2023-05

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